3KV2

HIGH RESOLUTION STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH THE STRONG INHIBITOR N(omega)-hydroxy-nor-L-arginine (nor-NOHA)

Summary for 3KV2

Entry DOI	10.2210/pdb3kv2/pdb
Descriptor	Arginase-1, MANGANESE (II) ION, NOR-N-OMEGA-HYDROXY-L-ARGININE, ... (4 entities in total)
Functional Keywords	strong inhibitor, nor-noha, arginase, high resolution, alternative splicing, arginine metabolism, cytoplasm, disease mutation, hydrolase, manganese, metal-binding, phosphoprotein, polymorphism, urea cycle
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P05089
Total number of polymer chains	2
Total formula weight	70131.86
Authors	Di Costanzo, L.,Christianson, D.W. (deposition date: 2009-11-28, release date: 2009-12-22, Last modification date: 2023-09-06)
Primary citation	Di Costanzo, L.,Ilies, M.,Thorn, K.J.,Christianson, D.W. Inhibition of human arginase I by substrate and product analogues. Arch.Biochem.Biophys., 496:101-108, 2010 Cited by PubMed: 20153713 DOI: 10.1016/j.abb.2010.02.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation