3KMM
Structure of human LCK kinase with a small molecule inhibitor
Summary for 3KMM
Entry DOI | 10.2210/pdb3kmm/pdb |
Related | 3LCK |
Descriptor | Proto-oncogene tyrosine-protein kinase LCK, 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | tyrosine kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, transferase, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P06239 |
Total number of polymer chains | 1 |
Total formula weight | 34134.64 |
Authors | Graves, B.J.,Surgenor, A.,Harris, W.,Smith, I.,Orchard, S.,Flotow, H.,Murray, E. (deposition date: 2009-11-10, release date: 2010-12-08, Last modification date: 2023-11-22) |
Primary citation | Graves, B.J.,Surgenor, A.,Harris, W.,Smith, I.,Orchard, S.,Flotow, H.,Murray, E. Structure of human LCK kinase with a small molecule inhibitor To be Published, |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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