3KMD
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer
Summary for 3KMD
Entry DOI | 10.2210/pdb3kmd/pdb |
Descriptor | Cellular tumor antigen p53, 5'-D(*GP*GP*GP*CP*AP*TP*GP*CP*CP*TP*AP*GP*GP*CP*AP*TP*GP*CP*C)-3', ZINC ION, ... (4 entities in total) |
Functional Keywords | p53 core domain, protein-dna interaction, self assembled tetramer, activator, apoptosis, cell cycle, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, isopeptide bond, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, tumor suppressor, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 6 |
Total formula weight | 102073.67 |
Authors | |
Primary citation | Chen, Y.,Dey, R.,Chen, L. Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. Structure, 18:246-256, 2010 Cited by PubMed: 20159469DOI: 10.1016/j.str.2009.11.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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