3KER

D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP

Summary for 3KER

Entry DOI	10.2210/pdb3ker/pdb
Related	1DPT 1MIF 3B64 3B9S 3KAN
Descriptor	D-dopachrome decarboxylase, 4-phenylpyrimidine, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	tautomerase, inflammation, cytokine, cytokine-inhibitor complex, cytokine/inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	4
Total formula weight	52982.04
Authors	Zierow, S.,Lolis, E. (deposition date: 2009-10-26, release date: 2010-10-13, Last modification date: 2023-09-06)
Primary citation	Rajasekaran, D.,Zierow, S.,Syed, M.,Bucala, R.,Bhandari, V.,Lolis, E.J. Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28:4961-4971, 2014 Cited by PubMed: 25016026 DOI: 10.1096/fj.14-256636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation