3KB7
Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor
Summary for 3KB7
Entry DOI | 10.2210/pdb3kb7/pdb |
Descriptor | Serine/threonine-protein kinase PLK1, 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | protein kinase, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 1 |
Total formula weight | 36323.56 |
Authors | Bossi, R.T.,Bertrand, J.A. (deposition date: 2009-10-20, release date: 2010-05-19, Last modification date: 2024-04-03) |
Primary citation | Beria, I.,Ballinari, D.,Bertrand, J.A.,Borghi, D.,Bossi, R.T.,Brasca, M.G.,Cappella, P.,Caruso, M.,Ceccarelli, W.,Ciavolella, A.,Cristiani, C.,Croci, V.,De Ponti, A.,Fachin, G.,Ferguson, R.D.,Lansen, J.,Moll, J.K.,Pesenti, E.,Posteri, H.,Perego, R.,Rocchetti, M.,Storici, P.,Volpi, D.,Valsasina, B. Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors J.Med.Chem., 53:3532-3551, 2010 Cited by PubMed: 20397705DOI: 10.1021/jm901713n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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