3K9X
X-ray crystal structure of human fxa in complex with (S)-N-((2-METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL)ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE
Summary for 3K9X
Entry DOI | 10.2210/pdb3k9x/pdb |
Related | 3ECN |
Descriptor | PROTEIN (Coagulation factor X), GLYCEROL, N-{N'-(2-methyl-1-benzofuran-5-yl)-N-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]carbamimidoyl}pyridine-3-carboxamide, ... (7 entities in total) |
Functional Keywords | serine protease, hydrolase, epidermal growth factor like domain, blood coagulation factor, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydroxylation, zymogen, blood clotting, blood coagulation, disulfide bond, protease, secreted |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 4 |
Total formula weight | 75881.82 |
Authors | Klei, H.E.,Kish, K.,Ghosh, K.,Rushith, A. (deposition date: 2009-10-16, release date: 2009-12-15, Last modification date: 2017-11-01) |
Primary citation | Shi, Y.,Li, C.,O'Connor, S.P.,Zhang, J.,Shi, M.,Bisaha, S.N.,Wang, Y.,Sitkoff, D.,Pudzianowski, A.T.,Huang, C.,Klei, H.E.,Kish, K.,Yanchunas, J.,Liu, E.C.,Hartl, K.S.,Seiler, S.M.,Steinbacher, T.E.,Schumacher, W.A.,Atwal, K.S.,Stein, P.D. Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577 Bioorg.Med.Chem.Lett., 19:6882-6889, 2009 Cited by PubMed: 19896847DOI: 10.1016/j.bmcl.2009.10.084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report