3K54
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases.
Summary for 3K54
Entry DOI | 10.2210/pdb3k54/pdb |
Descriptor | Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total) |
Functional Keywords | bruton's tyrosine kinase, btk, dasatinib, atp-binding, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 33134.42 |
Authors | Marcotte, D.J.,Liu, Y.-T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. (deposition date: 2009-10-06, release date: 2010-01-19, Last modification date: 2023-09-06) |
Primary citation | Marcotte, D.J.,Liu, Y.T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hong, V.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci., 19:429-439, 2010 Cited by PubMed: 20052711DOI: 10.1002/pro.321 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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