3K4V
New crystal form of HIV-1 Protease/Saquinavir structure reveals carbamylation of N-terminal proline
Summary for 3K4V
Entry DOI | 10.2210/pdb3k4v/pdb |
Related PRD ID | PRD_000454 |
Descriptor | HIV-1 Protease, DIMETHYL SULFOXIDE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ... (6 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, carbamylation, aids, aspartyl protease, capsid maturation, capsid protein, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 4 |
Total formula weight | 44706.43 |
Authors | Olajuyigbe, F.M.,Demitri, N.,Ajele, J.O.,Maurizio, E.,Randaccio, L.,Geremia, S. (deposition date: 2009-10-06, release date: 2010-06-09, Last modification date: 2023-09-06) |
Primary citation | Olajuyigbe, F.M.,Demitri, N.,Ajele, J.O.,Maurizio, E.,Randaccio, L.,Geremia, S. Carbamylation of N-terminal proline. ACS Med Chem Lett, 1:254-257, 2010 Cited by PubMed: 24900204DOI: 10.1021/ml100046d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.39 Å) |
Structure validation
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