3K3B
Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline
Summary for 3K3B
Entry DOI | 10.2210/pdb3k3b/pdb |
Descriptor | Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (8 entities in total) |
Functional Keywords | protein-ligand complex, atp-binding, cell cycle, cell division, microtubule, mitosis, motor protein, nucleotide-binding, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83920.53 |
Authors | Bussiere, D.E.,Bellamacina, C.,Le, V. (deposition date: 2009-10-02, release date: 2009-12-15, Last modification date: 2024-02-21) |
Primary citation | Barsanti, P.A.,Wang, W.,Ni, Z.J.,Duhl, D.,Brammeier, N.,Martin, E.,Bussiere, D.,Walter, A.O. The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5. Bioorg.Med.Chem.Lett., 20:157-160, 2010 Cited by PubMed: 19945875DOI: 10.1016/j.bmcl.2009.11.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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