3K2M

Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex

Summary for 3K2M

Entry DOI	10.2210/pdb3k2m/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, Monobody HA4, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, atp-binding, phosphoprotein, tyrosine-protein kinase, signaling protein, signaling protein-protein binding complex, signaling protein/protein binding
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	4
Total formula weight	47015.66
Authors	Wojcik, J.B.,Duguid, E. (deposition date: 2009-09-30, release date: 2010-03-31, Last modification date: 2023-09-06)
Primary citation	Wojcik, J.,Hantschel, O.,Grebien, F.,Kaupe, I.,Bennett, K.L.,Barkinge, J.,Jones, R.B.,Koide, A.,Superti-Furga, G.,Koide, S. A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17:519-527, 2010 Cited by PubMed: 20357770 DOI: 10.1038/nsmb.1793 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation