3K2F

Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

Summary for 3K2F

Entry DOI	10.2210/pdb3k2f/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
Functional Keywords	carbonic anhydrase, no-donating agent, antiglaucoma drug, sulfonamide, xray crystallography, lyase, acetylation, cytoplasm, disease mutation, metal-binding, polymorphism, zinc
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	30087.58
Authors	Temperini, C.,Cecchi, A. (deposition date: 2009-09-30, release date: 2009-11-17, Last modification date: 2023-11-01)
Primary citation	Steele, R.M.,Benedini, F.,Biondi, S.,Borghi, V.,Carzaniga, L.,Impagnatiello, F.,Miglietta, D.,Chong, W.K.,Rajapakse, R.,Cecchi, A.,Temperini, C.,Supuran, C.T. Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma Bioorg.Med.Chem.Lett., 19:6565-6570, 2009 Cited by PubMed: 19854054 DOI: 10.1016/j.bmcl.2009.10.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation