3JZS
Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ)
Summary for 3JZS
Entry DOI | 10.2210/pdb3jzs/pdb |
Related | 3JZO 3JZP 3JZQ 3JZR |
Descriptor | E3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer), 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | p53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 2 |
Total formula weight | 11798.77 |
Authors | Schonbrunn, E.,Phan, J. (deposition date: 2009-09-24, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Phan, J.,Li, Z.,Kasprzak, A.,Li, B.,Sebti, S.,Guida, W.,Schonbrunn, E.,Chen, J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285:2174-2183, 2010 Cited by PubMed: 19910468DOI: 10.1074/jbc.M109.073056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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