3JY0

Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors

Summary for 3JY0

• Entry DOI: 10.2210/pdb3jy0/pdb
• Related: 3JXW
• Descriptor: Proto-oncogene serine/threonine-protein kinase Pim-1, 8-chloro-2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}[1]benzothieno[3,2-d]pyrimidin-4(3H)-one (2 entities in total)
• Functional Keywords: pim-1, alternative initiation, atp-binding, cell membrane, cytoplasm, kinase, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 34299.33

Authors

Stoll, V.S. (deposition date: 2009-09-21, release date: 2009-11-10, Last modification date: 2024-02-21)

• Primary citation: Tao, Z.F.,Hasvold, L.,Leverson, J.,Han, E.,Guan, R.,Johson, E.F.,Stoll, V.S.,Stewart, K.D.,Stamper, G.,Soni, N.; Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)