3JW2
HIV-1 Protease Mutant G86S with DARUNAVIR
Summary for 3JW2
Entry DOI | 10.2210/pdb3jw2/pdb |
Related | 2IEN 3JVW 3JVY |
Descriptor | Gag-Pol polyprotein, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SODIUM ION, ... (5 entities in total) |
Functional Keywords | hiv-1 protease, mutant g86s, inhibitor, darunavir, aids, aspartyl protease, metal-binding, hydrolase |
Biological source | Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22147.51 |
Authors | Tie, Y.,Weber, I.T. (deposition date: 2009-09-17, release date: 2009-12-08, Last modification date: 2023-09-06) |
Primary citation | Ishima, R.,Gong, Q.,Tie, Y.,Weber, I.T.,Louis, J.M. Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease Proteins, 78:1015-1025, 2009 Cited by PubMed: 19899162DOI: 10.1002/prot.22625 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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