3JS2

Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid

Summary for 3JS2

Entry DOI	10.2210/pdb3js2/pdb
Descriptor	Basic fibroblast growth factor receptor 1, 5-(2-thienyl)nicotinic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	fibroblast growth factor, receptor tyrosine kinase, inhibitor, thienyl nicotinic acid, alternative splicing, atp-binding, chromosomal rearrangement, craniosynostosis, disease mutation, disulfide bond, dwarfism, glycoprotein, heparin-binding, hypogonadotropic hypogonadism, immunoglobulin domain, kallmann syndrome, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	2
Total formula weight	73053.61
Authors	Bae, J.H.,Ravindranathan, K.P.,Mandiyan, V.,Ekkati, A.R.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2009-09-09, release date: 2010-02-23, Last modification date: 2023-09-20)
Primary citation	Ravindranathan, K.P.,Mandiyan, V.,Ekkati, A.R.,Bae, J.H.,Schlessinger, J.,Jorgensen, W.L. Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening J.Med.Chem., 53:1662-1672, 2010 Cited by PubMed: 20121196 DOI: 10.1021/jm901386e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation