3JRX

Crystal structure of the BC domain of ACC2 in complex with soraphen A

Summary for 3JRX

Entry DOI	10.2210/pdb3jrx/pdb
Related	2HJW 3JRW
Descriptor	Acetyl-CoA carboxylase 2, SORAPHEN A (3 entities in total)
Functional Keywords	bc domain, soraphen a, alternative splicing, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, manganese, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system: O00763
Total number of polymer chains	1
Total formula weight	65943.96
Authors	Cho, Y.S.,Lee, J.I.,Shin, D.,Kim, H.T.,Lee, T.G.,Heo, Y.S. (deposition date: 2009-09-09, release date: 2010-01-12, Last modification date: 2023-11-01)
Primary citation	Cho, Y.S.,Lee, J.I.,Shin, D.,Kim, H.T.,Jung, H.Y.,Lee, T.G.,Kang, L.W.,Ahn, Y.J.,Cho, H.S.,Heo, Y.S. Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem.Biophys.Res.Commun., 391:187-192, 2010 Cited by PubMed: 19900410 DOI: 10.1016/j.bbrc.2009.11.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation