3JPV
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a pyrrolo[2,3-a]carbazole ligand
Summary for 3JPV
Entry DOI | 10.2210/pdb3jpv/pdb |
Descriptor | Proto-oncogene serine/threonine-protein kinase Pim-1, Peptide (PIMTIDE) ARKRRRHPSGPPTA, 1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde, ... (4 entities in total) |
Functional Keywords | oncogene, kinase, serine-threonine, pim1, pyrrolo[2, 3-a]carbazole, structural genomics consortium, sgc, alternative initiation, atp-binding, cell membrane, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, transferase - transferase inhibitor complex, transferase / transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 2 |
Total formula weight | 37417.60 |
Authors | Filippakopoulos, P.,Bullock, A.N.,Fedorov, O.,Akue-Gedu, R.,Rossignol, E.,Azzaro, S.,Bain, J.,Cohen, P.,Prudhomme, M.,Moreau, P.,Amizon, F.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-09-04, release date: 2009-10-27, Last modification date: 2023-09-06) |
Primary citation | Akue-Gedu, R.,Rossignol, E.,Azzaro, S.,Knapp, S.,Filippakopoulos, P.,Bullock, A.N.,Bain, J.,Cohen, P.,Prudhomme, M.,Anizon, F.,Moreau, P. Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new pim kinase inhibitors. J.Med.Chem., 52:6369-6381, 2009 Cited by PubMed: 19788246DOI: 10.1021/jm901018f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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