3ITN

Crystal structure of Pseudo-activated Procaspase-3

Summary for 3ITN

Entry DOI	10.2210/pdb3itn/pdb
Related PRD ID	PRD_000238
Descriptor	Caspase-3, ACETYL-ASP-GLU-VAL-ASP-CHLOROMETHYL KETONE inhibitor (3 entities in total)
Functional Keywords	caspase-3, apoptosis, hydrolase, phosphoprotein, protease, s-nitrosylation, thiol protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P42574
Total number of polymer chains	2
Total formula weight	29168.53
Authors	Walters, J.,Pop, C.,Scott, F.L.,Drag, M.,Swartz, P.D.,Mattos, C.,Salvesen, G.S.,Clark, A.C. (deposition date: 2009-08-28, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citation	Walters, J.,Pop, C.,Scott, F.L.,Drag, M.,Swartz, P.,Mattos, C.,Salvesen, G.S.,Clark, A.C. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem.J., 424:335-345, 2009 Cited by PubMed: 19788411 DOI: 10.1042/BJ20090825 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation