3ISG

Structure of the class D beta-lactamase OXA-1 in complex with doripenem

Summary for 3ISG

• Entry DOI: 10.2210/pdb3isg/pdb
• Descriptor: Beta-lactamase OXA-1, (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• Functional Keywords: hydrolase, lysine carboxylation, antibiotic resistance
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57370.88

Authors

Powers, R.A. (deposition date: 2009-08-25, release date: 2009-12-01, Last modification date: 2023-11-22)

• Primary citation: Schneider, K.D.,Karpen, M.E.,Bonomo, R.A.,Leonard, D.A.,Powers, R.A.; The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem.; Biochemistry, 48:11840-11847, 2009; PubMed: 19919101; DOI: 10.1021/bi901690r

Experimental method

X-RAY DIFFRACTION (1.4 Å)