3INX
HSP90 N-TERMINAL DOMAIN with pochoxime B
Summary for 3INX
Entry DOI | 10.2210/pdb3inx/pdb |
Related | 3INW |
Descriptor | Heat shock protein HSP 90-alpha, DIMETHYL SULFOXIDE, (5E,9E,11E)-14,16-dihydroxy-3,4,7,8-tetrahydro-1H-2-benzoxacyclotetradecine-1,11(12H)-dione 11-[O-(2-oxo-2-piperidin-1-ylethyl)oxime], ... (4 entities in total) |
Functional Keywords | alpha beta, 2-layer sandwich, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response, sp, ral, radicicol, pochonin, pochoxime |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 26271.65 |
Authors | Korndoerfer, I.P. (deposition date: 2009-08-13, release date: 2010-08-18, Last modification date: 2023-09-06) |
Primary citation | Barluenga, S.,Fontaine, J.G.,Wang, C.,Aouadi, K.,Chen, R.,Beebe, K.,Neckers, L.,Winssinger, N. Inhibition of HSP90 with pochoximes: SAR and structure-based insights. Chembiochem, 10:2753-2759, 2009 Cited by PubMed: 19856365DOI: 10.1002/cbic.200900494 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report