3IGG

Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2

Summary for 3IGG

• Entry DOI: 10.2210/pdb3igg/pdb
• Related: 3IG7
• Descriptor: Cell division protein kinase 2, N-[1-(cis-3-hydroxycyclobutyl)-1H-imidazol-4-yl]-2-(4-methoxyphenyl)acetamide (3 entities in total)
• Functional Keywords: protein kinase, transferase, serine/threonine protein kinase, inhibitor, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34303.87

Authors

Pandit, J. (deposition date: 2009-07-27, release date: 2009-09-08, Last modification date: 2011-07-13)

• Primary citation: Helal, C.J.,Kang, Z.,Lucas, J.C.,Gant, T.,Ahlijanian, M.K.,Schachter, J.B.,Richter, K.E.,Cook, J.M.,Menniti, F.S.,Kelly, K.,Mente, S.,Pandit, J.,Hosea, N.; Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.; Bioorg.Med.Chem.Lett., 19:5703-5707, 2009; PubMed: 19700321; DOI: 10.1016/j.bmcl.2009.08.019

Experimental method

X-RAY DIFFRACTION (1.8 Å)