3IBE

Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma

Summary for 3IBE

• Entry DOI: 10.2210/pdb3ibe/pdb
• Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, ... (4 entities in total)
• Functional Keywords: pi3kinase inhibitor, atp-binding, kinase, nucleotide-binding, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P48736
• Total number of polymer chains: 1
• Total formula weight: 111456.89

Authors

Bard, J.,Svenson, K. (deposition date: 2009-07-15, release date: 2009-09-01, Last modification date: 2023-09-06)

• Primary citation: Zask, A.,Verheijen, J.C.,Curran, K.,Kaplan, J.,Richard, D.J.,Nowak, P.,Malwitz, D.J.,Brooijmans, N.,Bard, J.,Svenson, K.,Lucas, J.,Toral-Barza, L.,Zhang, W.G.,Hollander, I.,Gibbons, J.J.,Abraham, R.T.,Ayral-Kaloustian, S.,Mansour, T.S.,Yu, K.; ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.; J.Med.Chem., 52:5013-5016, 2009; PubMed: 19645448; DOI: 10.1021/jm900851f

Experimental method

X-RAY DIFFRACTION (2.798 Å)