3I9O
Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose
Summary for 3I9O
Entry DOI | 10.2210/pdb3i9o/pdb |
Descriptor | ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (2 entities in total) |
Functional Keywords | homodimer, enzyme-reaction-intermediate complex, adp-ribosyl cyclase, disulfide bond, fertilization, hydrolase, nad |
Biological source | Aplysia californica (California sea hare) |
Cellular location | Cytoplasmic vesicle: P29241 |
Total number of polymer chains | 2 |
Total formula weight | 60250.50 |
Authors | Graeff, R.,Liu, Q.,Kriksunov, I.A.,Kotaka, M.,Oppenheimer, N.,Hao, Q.,Lee, H.C. (deposition date: 2009-07-12, release date: 2009-07-28, Last modification date: 2023-11-01) |
Primary citation | Graeff, R.,Liu, Q.,Kriksunov, I.A.,Kotaka, M.,Oppenheimer, N.,Hao, Q.,Lee, H.C. Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38 J.Biol.Chem., 284:27629-27636, 2009 Cited by PubMed: 19640843DOI: 10.1074/jbc.M109.030965 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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