3I7C
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NA-PP2
Summary for 3I7C
Entry DOI | 10.2210/pdb3i7c/pdb |
Related | 3I79 3I7B 3MWU 3N51 3NCG |
Descriptor | Calmodulin-domain protein kinase 1, 1-tert-butyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | protein kinase, calmodulin, ef hand, bumped kinase inhibitor, atp-binding, kinase, nucleotide-binding, serine/threonine-protein kinase, structural genomics, medical structural genomics of pathogenic protozoa, msgpp, transferase |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 1 |
Total formula weight | 56294.61 |
Authors | Larson, E.T.,Merritt, E.A.,Medical Structural Genomics of Pathogenic Protozoa (MSGPP) (deposition date: 2009-07-08, release date: 2010-02-09, Last modification date: 2023-11-22) |
Primary citation | Ojo, K.K.,Larson, E.T.,Keyloun, K.R.,Castaneda, L.J.,Derocher, A.E.,Inampudi, K.K.,Kim, J.E.,Arakaki, T.L.,Murphy, R.C.,Zhang, L.,Napuli, A.J.,Maly, D.J.,Verlinde, C.L.,Buckner, F.S.,Parsons, M.,Hol, W.G.,Merritt, E.A.,Van Voorhis, W.C. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat.Struct.Mol.Biol., 17:602-607, 2010 Cited by PubMed: 20436472DOI: 10.1038/nsmb.1818 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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