3I6U
Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase
Summary for 3I6U
Entry DOI | 10.2210/pdb3i6u/pdb |
Descriptor | Serine/threonine-protein kinase Chk2 (1 entity in total) |
Functional Keywords | ser/thr protein kinase, fha domain, atp-binding, cell cycle, disease mutation, kinase, li-fraumeni syndrome, magnesium, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017 |
Total number of polymer chains | 2 |
Total formula weight | 96226.20 |
Authors | Pavletich, N.P. (deposition date: 2009-07-07, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Cai, Z.,Chehab, N.H.,Pavletich, N.P. Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase. Mol.Cell, 35:818-829, 2009 Cited by PubMed: 19782031DOI: 10.1016/j.molcel.2009.09.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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