3I4B
Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor
Summary for 3I4B
Entry DOI | 10.2210/pdb3i4b/pdb |
Descriptor | Glycogen synthase kinase-3 beta, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide (3 entities in total) |
Functional Keywords | kinase, gsk3b, erk, pyrimidyl pyrrole, alternative splicing, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P49841 |
Total number of polymer chains | 2 |
Total formula weight | 93055.73 |
Authors | Ter Haar, E. (deposition date: 2009-07-01, release date: 2010-01-12, Last modification date: 2024-04-03) |
Primary citation | Aronov, A.M.,Tang, Q.,Martinez-Botella, G.,Bemis, G.W.,Cao, J.,Chen, G.,Ewing, N.P.,Ford, P.J.,Germann, U.A.,Green, J.,Hale, M.R.,Jacobs, M.,Janetka, J.W.,Maltais, F.,Markland, W.,Namchuk, M.N.,Nanthakumar, S.,Poondru, S.,Straub, J.,ter Haar, E.,Xie, X. Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52:6362-6368, 2009 Cited by PubMed: 19827834DOI: 10.1021/jm900630q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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