3I2S

Crystal structure of the hairpin ribozyme with a 2'OMe substrate and N1-deazaadenosine at position A10

Summary for 3I2S

• Entry DOI: 10.2210/pdb3i2s/pdb
• Related: 3I2P 3I2Q 3I2R 3I2U
• Descriptor: 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*GP*U)-3', DNA/RNA (30-MER), 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3', ... (5 entities in total)
• Functional Keywords: hairpin ribozyme, n1-deazaadenosine, rna
• Total number of polymer chains: 3
• Total formula weight: 20544.53

Authors

Wedekind, J.E.,Spitale, R.C.,Krucinska, J. (deposition date: 2009-06-29, release date: 2009-11-03, Last modification date: 2023-09-06)

• Primary citation: Spitale, R.C.,Volpini, R.,Mungillo, M.V.,Krucinska, J.,Cristalli, G.,Wedekind, J.E.; Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core.; Biochemistry, 48:7777-7779, 2009; PubMed: 19634899; DOI: 10.1021/bi9011622

Experimental method

X-RAY DIFFRACTION (2.75 Å)