3HI6

Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57

Summary for 3HI6

• Entry DOI: 10.2210/pdb3hi6/pdb
• Related: 3HI5
• Descriptor: Integrin alpha-L, Heavy chain of Fab fragment of AL-57 against alpha L I domain, light chain of Fab fragment of AL-57 against alpha L I domain, ... (6 entities in total)
• Functional Keywords: integrin, i domain, fab, ligand mimetic antibody, cell adhesion, alternative splicing, calcium, disulfide bond, glycoprotein, magnesium, membrane, polymorphism, receptor, transmembrane, cell adhesion-immune system complex, cell adhesion/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P20701
• Total number of polymer chains: 6
• Total formula weight: 135359.17

Authors

Zhang, H.,Wang, J. (deposition date: 2009-05-19, release date: 2009-09-22, Last modification date: 2021-10-13)

• Primary citation: Zhang, H.,Liu, J.H.,Yang, W.,Springer, T.,Shimaoka, M.,Wang, J.H.; Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1.; Proc.Natl.Acad.Sci.USA, 106:18345-18350, 2009; PubMed: 19805116; DOI: 10.1073/pnas.0909301106

Experimental method

X-RAY DIFFRACTION (2.3 Å)