3HEG
P38 in complex with Sorafenib
Summary for 3HEG
Entry DOI | 10.2210/pdb3heg/pdb |
Related | 3HEC |
Descriptor | Mitogen-activated protein kinase 14, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE (3 entities in total) |
Functional Keywords | transferases, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 40370.52 |
Authors | Namboodiri, H.V.,Karpusas, M. (deposition date: 2009-05-08, release date: 2009-11-10, Last modification date: 2023-09-06) |
Primary citation | Namboodiri, H.V.,Bukhtiyarova, M.,Ramcharan, J.,Karpusas, M.,Lee, Y.,Springman, E.B. Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49:3611-3618, 2010 Cited by PubMed: 20337484DOI: 10.1021/bi100070r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report