3H3C
Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog
Summary for 3H3C
Entry DOI | 10.2210/pdb3h3c/pdb |
Descriptor | Protein tyrosine kinase 2 beta, SULFATE ION, 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide, ... (4 entities in total) |
Functional Keywords | pyk2, kinase, alternative splicing, atp-binding, cell membrane, cytoplasm, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q14289 |
Total number of polymer chains | 1 |
Total formula weight | 33129.14 |
Authors | Han, S.,Mistry, A. (deposition date: 2009-04-16, release date: 2009-05-26, Last modification date: 2024-02-21) |
Primary citation | Walker, D.P.,Zawistoski, M.P.,McGlynn, M.A.,Li, J.C.,Kung, D.W.,Bonnette, P.C.,Baumann, A.,Buckbinder, L.,Houser, J.A.,Boer, J.,Mistry, A.,Han, S.,Xing, L.,Guzman-Perez, A. Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. Bioorg.Med.Chem.Lett., 19:3253-3258, 2009 Cited by PubMed: 19428251DOI: 10.1016/j.bmcl.2009.04.093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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