3H2E

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

Summary for 3H2E

Entry DOI	10.2210/pdb3h2e/pdb
Related	1TWS 1TWW 1TWZ 1TX0 1TX2 3H21 3H22 3H23 3H24 3H26 3H2A 3H2C 3H2F 3H2M 3H2N 3H2O
Descriptor	Dihydropteroate synthase, SULFATE ION, 1,3-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropteridine-6-carbaldehyde, ... (4 entities in total)
Functional Keywords	anthracis, folate biosynthesis, dihydropteroate, pterine, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bacillus anthracis str. A2012
Total number of polymer chains	2
Total formula weight	67008.34
Authors	Yun, M.-K.,White, S.W. (deposition date: 2009-04-14, release date: 2009-12-08, Last modification date: 2023-09-06)
Primary citation	Hevener, K.E.,Yun, M.K.,Qi, J.,Kerr, I.D.,Babaoglu, K.,Hurdle, J.G.,Balakrishna, K.,White, S.W.,Lee, R.E. Structural studies of pterin-based inhibitors of dihydropteroate synthase. J.Med.Chem., 53:166-177, 2010 Cited by PubMed: 19899766 DOI: 10.1021/jm900861d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation