3GYU
Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 7
Summary for 3GYU
Entry DOI | 10.2210/pdb3gyu/pdb |
Related | 3GYT |
Descriptor | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily, SRC1, (5beta,14beta,17alpha,25R)-3-oxocholest-7-en-26-oic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, ligand binding domain, dafachronic acid, src1, nematode, strongyloides stercoralis, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger |
Biological source | Strongyloides stercoralis |
Cellular location | Nucleus : Q9XZJ5 |
Total number of polymer chains | 2 |
Total formula weight | 30088.36 |
Authors | Zhou, X.E.,Wang, Z.,Suino-Powell, K.,Motola, D.L.,Conneely, A.,Ogata, C.,Sharma, K.K.,Auchus, R.J.,Kliewer, S.A.,Xu, H.E.,Mangelsdorf, D.J. (deposition date: 2009-04-05, release date: 2009-07-07, Last modification date: 2024-04-03) |
Primary citation | Wang, Z.,Zhou, X.E.,Motola, D.L.,Gao, X.,Suino-Powell, K.,Conneely, A.,Ogata, C.,Sharma, K.K.,Auchus, R.J.,Lok, J.B.,Hawdon, J.M.,Kliewer, S.A.,Xu, H.E.,Mangelsdorf, D.J. Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc.Natl.Acad.Sci.USA, 106:9138-9143, 2009 Cited by PubMed: 19497877DOI: 10.1073/pnas.0904064106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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