3GKI

NPC1(NTD):cholesterol

Summary for 3GKI

Entry DOI	10.2210/pdb3gki/pdb
Related	3GKH 3GKJ
Descriptor	Niemann-Pick C1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cholesterol, cholesterol transfer, disease mutation, endosome, glycoprotein, lysosome, membrane, transmembrane, transport protein
Biological source	Homo sapiens (human)
Cellular location	Late endosome membrane; Multi-pass membrane protein: O15118
Total number of polymer chains	1
Total formula weight	26771.20
Authors	Kwon, H.J. (deposition date: 2009-03-10, release date: 2009-07-14, Last modification date: 2021-10-20)
Primary citation	Kwon, H.J.,Abi-Mosleh, L.,Wang, M.L.,Deisenhofer, J.,Goldstein, J.L.,Brown, M.S.,Infante, R.E. Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell(Cambridge,Mass.), 137:1213-1224, 2009 Cited by PubMed: 19563754 DOI: 10.1016/j.cell.2009.03.049 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation