3GI0

Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [l-ala51,d-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor

Summary for 3GI0

• Entry DOI: 10.2210/pdb3gi0/pdb
• Related: 3FSM
• Related PRD ID: PRD_000228
• Descriptor: COVALENT DIMER [L-ALA51,D-ALA51'] HIV-1 PROTEASE, JG-365 inhibitor (3 entities in total)
• Functional Keywords: beta-barrel, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 4
• Total formula weight: 45529.48

Authors

Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-03-04, release date: 2011-08-10, Last modification date: 2023-11-15)

• Primary citation: Torbeev, V.Y.,Kent, S.B.H.; Correlations of protein dynamics with function in HIV-1 protease catalysis; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)