3GEY

Crystal structure of human poly(ADP-ribose) polymerase 15, catalytic fragment in complex with an inhibitor Pj34

Summary for 3GEY

• Entry DOI: 10.2210/pdb3gey/pdb
• Related: 3BLJ
• Descriptor: Poly [ADP-ribose] polymerase 15, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE (3 entities in total)
• Functional Keywords: parp, poly(adp-ribose) polymerase, bal-3, sgc, structural genomics consortium, glycosyltransferase, nad, nucleus, transcription, transcription regulation, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q460N3
• Total number of polymer chains: 4
• Total formula weight: 102348.51

Authors

Karlberg, T.,Siponen, M.I.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Schutz, P.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-02-26, release date: 2009-03-24, Last modification date: 2023-09-06)

• Primary citation: Karlberg, T.,Klepsch, M.,Thorsell, A.G.,Andersson, C.D.,Linusson, A.,Schuler, H.; Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein.; J.Biol.Chem., 290:7336-7344, 2015; PubMed: 25635049; DOI: 10.1074/jbc.M114.630160

Experimental method

X-RAY DIFFRACTION (2.2 Å)