3GEN
The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound
Summary for 3GEN
Entry DOI | 10.2210/pdb3gen/pdb |
Descriptor | Tyrosine-protein kinase BTK, 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane (3 entities in total) |
Functional Keywords | bruton's tyrosine kinase, 4-amino-5-(4-phenoxyphenyl)-5h-pyrrolo[3, 2-d]pyrimidin-7-yl-cyclopentane, tec-family, complex, acetylation, atp-binding, cytoplasm, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, polymorphism, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, zinc, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 33050.92 |
Authors | Marcotte, D.J.,Liu, Y.T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hopkins, B.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. (deposition date: 2009-02-25, release date: 2010-01-19, Last modification date: 2024-03-13) |
Primary citation | Marcotte, D.J.,Liu, Y.T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hong, V.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci., 19:429-439, 2010 Cited by PubMed: 20052711DOI: 10.1002/pro.321 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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