3GD2

isoxazole ligand bound to farnesoid X receptor (FXR)

Summary for 3GD2

• Entry DOI: 10.2210/pdb3gd2/pdb
• Descriptor: Bile acid receptor, activator peptide, 3-[(E)-2-(2-chloro-4-{[3-{[(R)-(2,6-dichlorophenyl)(hydroxy)-lambda~4~-sulfanyl]methyl}-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid, ... (4 entities in total)
• Functional Keywords: fxr, nuclear recptor, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription, transcription regulation, zinc, zinc-finger, transcription-transcription activator complex, transcription/transcription activator
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1
• Total number of polymer chains: 2
• Total formula weight: 28678.06

Authors

Madauss, K.P.,Williams, S.P.,Deaton, D.N.,Wisely, G.B.,Mcfadyen, R.B. (deposition date: 2009-02-23, release date: 2009-07-07, Last modification date: 2024-02-21)

• Primary citation: Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,Parks, D.J.,Todd, D.,Williams, S.P.,Wisely, G.B.; Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.; Bioorg.Med.Chem.Lett., 19:2969-2973, 2009; PubMed: 19410460; DOI: 10.1016/j.bmcl.2009.04.047

Experimental method

X-RAY DIFFRACTION (3.2 Å)