3GC6
Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.
Summary for 3GC6
| Entry DOI | 10.2210/pdb3gc6/pdb |
| Descriptor | Ecto-NAD+ glycohydrolase (CD38 molecule), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | cd38, cyclic adp ribose, ecto-adp-ribosyl cyclase, glycosidase, hydrolase |
| Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
| Total number of polymer chains | 2 |
| Total formula weight | 57929.24 |
| Authors | Egea, P.F.,Muller-Steffner, H.,Stroud, R.M.,Oppenheimer, N.,Kellenberger, E.,Schuber, F. (deposition date: 2009-02-21, release date: 2010-03-02, Last modification date: 2023-09-06) |
| Primary citation | Egea, P.F.,Muller-Steffner, H.,Kuhn, I.,Cakir-Kiefer, C.,Oppenheimer, N.J.,Stroud, R.M.,Kellenberger, E.,Schuber, F. Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. Plos One, 7:e34918-e34918, 2012 Cited by PubMed: 22529956DOI: 10.1371/journal.pone.0034918 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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