Summary for 3G8O
Entry DOI | 10.2210/pdb3g8o/pdb |
Related | 3HQ5 |
Descriptor | Progesterone receptor, N~2~-[4-cyano-3-(trifluoromethyl)phenyl]-N,N-dimethyl-N~2~-(2,2,2-trifluoroethyl)-L-alaninamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | progesterone receptor, steroid hormone receptor, nuclear receptor, pr, progesterone, alpha helical sandwich, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, receptor, steroid-binding, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus. Isoform A: Nucleus. Isoform 4: Mitochondrion outer membrane : P06401 |
Total number of polymer chains | 2 |
Total formula weight | 61387.44 |
Authors | Thompson, S.K.,Washburn, D.G.,Madauss, K.P.,Williams, S.P.,Stewart, E.L. (deposition date: 2009-02-12, release date: 2010-02-16, Last modification date: 2023-09-06) |
Primary citation | Thompson, S.K.,Washburn, D.G.,Frazee, J.S.,Madauss, K.P.,Hoang, T.H.,Lapinski, L.,Grygielko, E.T.,Glace, L.E.,Trizna, W.,Williams, S.P.,Duraiswami, C.,Bray, J.D.,Laping, N.J. Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists. Bioorg.Med.Chem.Lett., 19:4777-4780, 2009 Cited by PubMed: 19595590DOI: 10.1016/j.bmcl.2009.06.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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