3G1V
Crystal structure of the mutant D70G of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 5-fluorouridine 5'-monophosphate
Summary for 3G1V
Entry DOI | 10.2210/pdb3g1v/pdb |
Related | 3G18 3G1A 3G1D 3G1F 3G1H 3G1S 3G1X 3G1Y 3G22 3G24 |
Descriptor | Orotidine 5'-phosphate decarboxylase, 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | orotidine 5'-monophosphate decarboxylase, d70g, 5-fluorouridine 5'-monophosphate, decarboxylase, pyrimidine biosynthesis, lyase |
Biological source | Methanothermobacter thermautotrophicus str. Delta H |
Total number of polymer chains | 2 |
Total formula weight | 50408.57 |
Authors | Fedorov, A.A.,Fedorov, E.V.,Chan, K.K.,Gerlt, J.A.,Almo, S.C. (deposition date: 2009-01-30, release date: 2009-06-23, Last modification date: 2023-09-06) |
Primary citation | Chan, K.K.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Imker, H.J.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48:5518-5531, 2009 Cited by PubMed: 19435314DOI: 10.1021/bi900623r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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