3FXV
Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist
Summary for 3FXV
Entry DOI | 10.2210/pdb3fxv/pdb |
Descriptor | NR1H4 protein, 12-meric peptide from Nuclear receptor coactivator 1, 6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, cholesterol, bile acid, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, hormone receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 29311.53 |
Authors | Feng, S.,Yang, M.,He, Y.,Chen, L.,Zhang, Z.,Wang, Z.,Hong, D.,Richter, H.,Benson, G.M.,Bleicher, K.,Grether, U.,Martin, R.,Plancher, J.-M.,Kuhn, B.,Rudolph, M.G. (deposition date: 2009-01-21, release date: 2009-04-14, Last modification date: 2024-04-03) |
Primary citation | Feng, S.,Yang, M.,Zhang, Z.,Wang, Z.,Hong, D.,Richter, H.,Benson, G.M.,Bleicher, K.,Grether, U.,Martin, R.E.,Plancher, J.-M.,Kuhn, B.,Rudolph, M.G.,Chen, L. Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist Bioorg.Med.Chem.Lett., 19:2595-2598, 2009 Cited by PubMed: 19328688DOI: 10.1016/j.bmcl.2009.03.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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