3FPD
G9a-like protein lysine methyltransferase inhibition by BIX-01294
Summary for 3FPD
Entry DOI | 10.2210/pdb3fpd/pdb |
Related | 2RFI |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine, ... (5 entities in total) |
Functional Keywords | epigenetics, histone lysine methylation, catalytic set domain, inhibition by bix-01294, alternative splicing, ank repeat, chromatin regulator, metal-binding, methyltransferase, nucleus, phosphoprotein, polymorphism, s-adenosyl-l-methionine, transferase, zinc |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9H9B1 |
Total number of polymer chains | 2 |
Total formula weight | 62738.12 |
Authors | Chang, Y.,Zhang, X.,Horton, J.R.,Cheng, X. (deposition date: 2009-01-05, release date: 2009-02-17, Last modification date: 2023-09-06) |
Primary citation | Chang, Y.,Zhang, X.,Horton, J.R.,Upadhyay, A.K.,Spannhoff, A.,Liu, J.,Snyder, J.P.,Bedford, M.T.,Cheng, X. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat.Struct.Mol.Biol., 16:312-317, 2009 Cited by PubMed: 19219047DOI: 10.1038/nsmb.1560 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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