3FLW
P38 kinase crystal structure in complex with pamapimod
Summary for 3FLW
Entry DOI | 10.2210/pdb3flw/pdb |
Related | 3FLN 3FLQ 3FLS 3FLY 3FLZ 3FMH 3FMJ 3FMK |
Descriptor | Mitogen-activated protein kinase 14, 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total) |
Functional Keywords | p38; map kinase; serine/threonine kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 43155.10 |
Authors | Kuglstatter, A.,Ghate, M. (deposition date: 2008-12-19, release date: 2009-12-22, Last modification date: 2024-02-21) |
Primary citation | Soth, M.,Kuglstatter, A.,Goldstein, D. The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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