3FDL

Bim BH3 peptide in complex with Bcl-xL

Summary for 3FDL

Entry DOI	10.2210/pdb3fdl/pdb
Related	3FDM
Descriptor	Apoptosis regulator Bcl-X, Bcl-2-like protein 11 (3 entities in total)
Functional Keywords	helical bundle, peptide-protein complex, apoptosis, alternative splicing, membrane, mitochondrion, nucleus, transmembrane, phosphoprotein
Biological source	Homo sapiens (Human) More
Cellular location	Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
Total number of polymer chains	2
Total formula weight	21192.65
Authors	Fairlie, W.D.,Lee, E.F.,Smith, B.J.,Czabotar, P.E.,Colman, P.M. (deposition date: 2008-11-26, release date: 2009-03-10, Last modification date: 2023-11-01)
Primary citation	Lee, E.F.,Sadowsky, J.D.,Smith, B.J.,Czabotar, P.E.,Peterson-Kaufman, K.J.,Colman, P.M.,Gellman, S.H.,Fairlie, W.D. High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L) Angew.Chem.Int.Ed.Engl., 48:4318-4322, 2009 Cited by PubMed: 19229915 DOI: 10.1002/anie.200805761 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation