3FAL
humanRXR alpha & mouse LXR alpha complexed with Retenoic acid and GSK2186
Summary for 3FAL
Entry DOI | 10.2210/pdb3fal/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Oxysterols receptor LXR-alpha, RETINOIC ACID, ... (5 entities in total) |
Functional Keywords | nuclear hormone receptor nonsteroidal lxr agonist choloestorol metabolism, dna-binding, host-virus interaction, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P19793 Nucleus (Potential): Q9Z0Y9 |
Total number of polymer chains | 4 |
Total formula weight | 117065.62 |
Authors | Chao, E.Y.,Caravella, J.A.,Watson, M.A.,Campobasso, N.,Ghisletti, S.,Billin, A.N.,Galardi, C.,Willson, T.M.,Zuercher, W.J.,Collins, J.L. (deposition date: 2008-11-17, release date: 2009-04-14, Last modification date: 2023-12-27) |
Primary citation | Chao, E.Y.,Caravella, J.A.,Watson, M.A.,Campobasso, N.,Ghisletti, S.,Billin, A.N.,Galardi, C.,Wang, P.,Laffitte, B.A.,Iannone, M.A.,Goodwin, B.J.,Nichols, J.A.,Parks, D.J.,Stewart, E.,Wiethe, R.W.,Williams, S.P.,Smallwood, A.,Pearce, K.H.,Glass, C.K.,Willson, T.M.,Zuercher, W.J.,Collins, J.L. Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J.Med.Chem., 51:5758-5765, 2008 Cited by PubMed: 18800767DOI: 10.1021/jm800612u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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