3F80

(S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal coordination interactions in the binuclear manganese cluster. Resolution 1.60 A.

Summary for 3F80

Entry DOI	10.2210/pdb3f80/pdb
Descriptor	Arginase-1, MANGANESE (II) ION, 6-nitro-L-norleucine, ... (4 entities in total)
Functional Keywords	nitronium group coordination, surface plasmon resonance, alternative splicing, arginine metabolism, cytoplasm, disease mutation, hydrolase, manganese, metal-binding, phosphoprotein, polymorphism, urea cycle
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P05089
Total number of polymer chains	2
Total formula weight	70131.85
Authors	Di Costanzo, L.,Christianson, D.W. (deposition date: 2008-11-10, release date: 2008-12-02, Last modification date: 2023-09-06)
Primary citation	Zakharian, T.Y.,Di Costanzo, L.,Christianson, D.W. (S)-2-Amino-6-nitrohexanoic Acid Binds to Human Arginase I through Multiple Nitro-Metal Coordination Interactions in the Binuclear Manganese Cluster. J.Am.Chem.Soc., 130:17254-17255, 2008 Cited by PubMed: 19032027 DOI: 10.1021/ja807702q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation