3F5P

Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor

Summary for 3F5P

• Entry DOI: 10.2210/pdb3f5p/pdb
• Related: 2ZM3
• Descriptor: Insulin-like growth factor 1 receptor, 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile (3 entities in total)
• Functional Keywords: igf-1r, protein-inhibitor complex, tyrosine kinase, atp-binding, cleavage on pair of basic residues, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 574323.54

Authors

Xu, W.,Miller, L.M.,Mayer, S.C.,Berger, D.M.,Boschelli, D.H.,Boschelli, F. (deposition date: 2008-11-04, release date: 2008-12-30, Last modification date: 2023-11-15)

• Primary citation: Miller, L.M.,Mayer, S.C.,Berger, D.M.,Boschelli, D.H.,Boschelli, F.,Di, L.,Du, X.,Dutia, M.,Floyd, M.B.,Johnson, M.,Kenny, C.H.,Krishnamurthy, G.,Moy, F.,Petusky, S.,Tkach, D.,Torres, N.,Wu, B.,Xu, W.; Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment; Bioorg.Med.Chem.Lett., 19:62-66, 2009; PubMed: 19041240; DOI: 10.1016/j.bmcl.2008.11.037

Experimental method

X-RAY DIFFRACTION (2.9 Å)