3EO1
Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3
Summary for 3EO1
| Entry DOI | 10.2210/pdb3eo1/pdb |
| Related | 3EO0 |
| Descriptor | GC-1008 Fab Light Chain, GC-1008 Fab Heavy Chain, Transforming growth factor beta-3 (3 entities in total) |
| Functional Keywords | antibody-cytokine complex, growth factor, fab fragment, cardiomyopathy, cleavage on pair of basic residues, glycoprotein, mitogen, polymorphism, secreted, immune system-cytokine complex, immune system/cytokine |
| Biological source | Mus musculus More |
| Cellular location | Secreted: P10600 |
| Total number of polymer chains | 12 |
| Total formula weight | 239996.87 |
| Authors | Gruetter, C.,Gruetter, M.G. (deposition date: 2008-09-26, release date: 2008-12-02, Last modification date: 2023-11-01) |
| Primary citation | Wilkinson, T.,Turner, R.,Podichetty, S.,Finch, D.,McCourt, M.,Loning, S.,Jermutus, L. A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions Proc.Natl.Acad.Sci.Usa, 105:20251-20256, 2008 Cited by PubMed: 19073914DOI: 10.1073/pnas.0807200106 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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