3EM3

Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).

Summary for 3EM3

• Entry DOI: 10.2210/pdb3em3/pdb
• Related: 3EKP 3EKQ 3EKT 3EKV 3EKW 3EKX 3EKY 3EL0 3EL1 3EL4 3EL5 3EM4 3EM6
• Descriptor: Protease, ACETATE ION, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ... (4 entities in total)
• Functional Keywords: protease inhibitor, hyper susceptibility, drug resistance, hiv, amprenavir, aids, hydrolase, protease
• Biological source: HIV-1 M:B_ARV2/SF2 (HIV-1)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22429.49

Authors

Prabu-Jeyabalan, M.,King, N.,Royer, C.,Schiffer, C. (deposition date: 2008-09-23, release date: 2009-09-01, Last modification date: 2023-09-06)

• Primary citation: Prabu-Jeyabalan, M.,King, N.,Bandaranayake, R.,Nalivaika, E.,Schiffer, C.; Kinetic and Structural Studies on Atazanavir-specific I50L Drug-Resistant HIV-1 Protease Mutant; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)