3EGK
KNOBLE Inhibitor
Summary for 3EGK
Entry DOI | 10.2210/pdb3egk/pdb |
Related | 1H8D 1K22 1YPG 2ZDA 2ZGX 2ZHQ |
Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total) |
Functional Keywords | blood clotting/hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, blood clotting-hydrolase inhibitor complex |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P01050 |
Total number of polymer chains | 3 |
Total formula weight | 35754.08 |
Authors | Baum, B.,Heine, A.,Klebe, G.,Muenzel, M. (deposition date: 2008-09-10, release date: 2008-09-30, Last modification date: 2023-11-15) |
Primary citation | Gerlach, C.,Munzel, M.,Baum, B.,Gerber, H.-D.,Craan, T.,Diederich, W.E.,Klebe, G. KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding Angew.Chem.Int.Ed.Engl., 46:9105-9109, 2007 Cited by PubMed: 17955562DOI: 10.1002/anie.200703323 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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